Full-Spectrum NGS Microbiome Intelligence
Your microbiome
decoded at the
deepest level.
Shotgun metagenomics with AI-generated dynamic biomarkers — each backed by clinical study references, personalised to your biology. Virome, mycobiome, archaeome, resistome, and functional gene pathways. The only consumer test that shows you what your microbiome is doing, not just who lives there.
0M+
Reads per sample
0
Report categories
0K+
Microbial species
CLIA
Certified lab
Process
From sample to intelligence
in 10 days.
A simple at-home collection. Lab-grade analysis. A report that tells you what to do about it.
Step 01
Order & Collect
Your kit arrives within 3 days. Collection takes under 5 minutes using our stool collection system. Stabilisation buffer preserves your sample at room temperature for up to 14 days.
Step 02
Shotgun Sequencing
Your sample is processed in our CLIA-certified partner lab using Illumina shotgun metagenomics. 35 million reads capture bacteria, viruses, fungi, archaea, and resistance genes simultaneously.
Step 03
AI Analysis
Our AI pipeline runs HUMAnN3 for functional gene pathways, VirSorter2 for virome, CARD database for resistome, and cross-references your pattern against our growing reference cohort.
Step 04
Your Report
A 35+ page personalised report with clinical references, severity-tiered findings, actionable interventions ranked by evidence, and a longitudinal tracking dashboard for future tests.
AI Interpretation Engine
Biomarkers that adapt
to your biology.
Standard tests apply static reference ranges to everyone. Our AI generates personalised biomarker interpretations drawn from your unique data cross-referenced against clinical literature — updated as the science evolves.
Dynamic · Not Static
Personalised reference ranges
Rather than applying population-average thresholds, our AI contextualises your results against your age, sex, reported symptoms, dietary patterns, and prior test history to generate ranges meaningful to your physiology specifically.
Literature-Grounded
Every biomarker cites its evidence base
Each AI-generated interpretation links directly to peer-reviewed studies. Evidence is tiered — Established (multiple human RCTs), Supported (observational + mechanistic), or Emerging (early-stage science) — so you know exactly how much confidence to place in each finding.
Cross-Pattern AI
Cluster findings invisible as single markers
The most clinically significant findings are patterns — not individual markers. Our AI detects co-occurrence signatures like the oral-gut translocation cluster (5 oral anaerobes simultaneously elevated) that no single biomarker threshold would catch.
Established
Multiple Human RCTs
Two or more randomised controlled trials in humans confirm the association. Highest confidence tier. Examples: L. reuteri serotonin RCTs, B. longum 1714 stress study, TMAO cardiovascular cohorts.
Supported
Observational + Mechanistic
Consistent observational human data plus mechanistic animal or in vitro studies. Moderate confidence. Examples: beta-glucuronidase estrogen recirculation, oxalate degradation and joint pain, H₂S gut barrier disruption.
Emerging
Early-Stage Science
Animal studies or small human pilots with promising but unconfirmed associations. Always disclosed clearly. Examples: vagal tone taxa, sleep architecture microbiome links, quorum sensing in dysbiosis.
Coverage
The only test that covers
all six kingdoms.
Standard 16S tests see about 40% of your microbiome. Biomeshield sees everything — including the domains that matter most for your health and are invisible to every competitor.
Core
Bacteriome
Species-level resolution of your bacterial community with strain-level identification for clinically relevant organisms. Functional gene pathway output from HUMAnN3 UniRef90 database.
SCFA genesLPS burdenBile acid transform.H₂S genesGABA synthesisTryptophan fateButyrate capacity
Exclusive
Virome
Bacteriophage community profiling via VirSorter2. CrAssphage abundance, phage-to-bacteria ratio, lytic vs lysogenic balance. No consumer test currently reports this data.
CrAssphagePhage:bacteria ratioLytic/lysogenicNovel phage
Exclusive
Mycobiome
Fungal community via ITS co-extraction. Candida species ratios, Saccharomyces presence, fungi-to-bacteria ratio. Candida parapsilosis and C. albicans distinguished by clinical profile.
Candida spp.S. cerevisiaeMalasseziaFungi:bacteria ratio
Exclusive
Archaeome
Methanogen profiling invisible to standard 16S V3-V4 primers. Classifies your fermentation type — hydrogen-dominant vs methane-dominant — with direct SIBO subtyping implications.
M. smithiiFermentation typeSIBO subtypeTransit time proxy
Exclusive
Resistome
Full antibiotic resistance gene (ARG) profiling via CARD database. Tetracycline, macrolide, beta-lactam, vancomycin, and carbapenem resistance genes quantified. Post-antibiotic recovery tracking.
tetW / tetMermBblaOXAvanANDM-1
Core
Pathogen Surveillance
Dynamic detection of 200+ pathobionts at species and strain level, referenced against population percentiles. AI co-occurrence pattern detection flags cluster findings invisible as single markers.
Percentile rankedFold-excessClinical referencesPMIDsCluster detection
Sample Report
Not a score.
A clinical narrative.
Every finding is personalised to your actual abundance values, referenced to population percentiles, and explained in plain language with the science behind it.
Personalised to your data
Abundance values, fold-excesses, and percentile ranks pulled directly from your NGS output. No template language — every sentence is specific to your results.
AI cross-pattern detection
Our AI identifies co-occurrence patterns invisible as single markers — like the oral-gut translocation cluster that appears when 5 oral anaerobes are simultaneously elevated in the gut.
Clinical references with PMIDs
Every finding cites peer-reviewed literature. PMIDs are provided so you and your practitioner can verify the evidence base directly.
Test-over-test tracking
Every marker tracked longitudinally. See your trajectory, measure intervention impact, and watch your microbiome respond to dietary and supplemental changes.
The Science
Built on the same
infrastructure as
research labs.
We white-label CLIA-certified shotgun metagenomics and run it through open-source validated bioinformatics pipelines — the same tools used in peer-reviewed microbiome research.
0
Reads per sample — 10× more than standard 16S
0
Species-level taxonomic classification accuracy
0
Biological kingdoms profiled per sample
0
Pathobionts tracked with population percentiles
Analysis Pipeline
1
DNA Extraction & Sequencing
ZymoBIOMICS protocol for low-bias extraction. Illumina NovaSeq 6000 paired-end sequencing. 35M reads standard; 70M reads for Elite tier.
2
Taxonomic Classification
QIIME2 + DADA2 for 16S compatibility reference. Kraken2 + Bracken for shotgun species-level classification against SILVA 138 and RefSeq databases.
3
Functional Gene Profiling
HUMAnN3 against UniRef90 for metabolic pathway reconstruction. SCFA gene families, tryptophan fate partitioning, GABA synthesis genes, bile acid transformation capacity.
4
Virome / Mycobiome / Resistome
VirSorter2 for phage detection. ITS2 co-extraction for fungi. CARD database v3.2 for ARG profiling. All six kingdoms from a single stool sample.
5
AI Report Generation
Cross-pattern detection across all categories. Population percentile ranking against our reference cohort. Personalised narrative generation with evidence-tiered intervention recommendations.
Comparison
How Biomeshield compares
to the alternatives.
Most consumer tests use 16S amplicon sequencing — a 30-year-old technology that misses fungi, viruses, archaea, and resistance genes entirely. None generate AI-personalised dynamic biomarkers with clinical study references.
| Feature | Biomeshield | Viome | Microba | Thorne/Onegevity | Biomesight | Ombre / Floré |
|---|---|---|---|---|---|---|
| Sequencing method | Shotgun metagenomics | Metatranscriptomics | Shotgun metagenomics | Shotgun metagenomics | 16S amplicon | 16S amplicon |
| Species-level resolution | ✓ | ✓ | ✓ | Partial | ✗ Genus only | ✗ Genus only |
| Functional gene pathways | ✓ HUMAnN3 | ✓ RNA-based | Limited | Limited | ✗ | ✗ |
| AI dynamic biomarkers | ✓ Personalised | Proprietary scores | ✗ | ✗ | ✗ | ✗ |
| Clinical references (PMIDs) | ✓ Every finding | ✗ | Some | ✗ | Some | ✗ |
| Virome profiling | ✓ VirSorter2 | ✗ | ✗ | ✗ | ✗ | ✗ |
| Mycobiome (fungi) | ✓ ITS co-extraction | ✗ | ✗ | ✗ | ✗ | ✗ |
| Archaeome / methanogens | ✓ | ✗ | Partial | ✗ | ✗ | ✗ |
| Resistome / ARG profiling | ✓ CARD database | ✗ | ✗ | ✗ | ✗ | ✗ |
| Pathogen percentile ranking | ✓ 200+ organisms | Limited | Limited | Limited | Basic | ✗ |
| AI co-occurrence patterns | ✓ | ✗ | ✗ | ✗ | ✗ | ✗ |
| Longitudinal tracking | ✓ | ✓ | ✓ | Limited | ✓ | Basic |
| Price | From $199 | $149–$299 | ~$180 AUD | $248+ | £149–£199 | $99–$149 |
Pricing
One test. Three depths
of intelligence.
All tiers use the same CLIA-certified shotgun metagenomics. The difference is sequencing depth, category coverage, and consultation access.
No products available right now. Please ensure the backend is running and products are published.
All tests include free shipping both ways · Results in 10–14 days · CLIA-certified lab
Early Access
Brain fog. Afternoon crashes.
Bloating that makes no sense.
These aren't mysteries. They're measurable organisms, specific toxins, and identifiable gene pathways. Biomeshield shows you exactly what's driving them — with the clinical studies to prove it.
⏳ Founding member pricing locks in 20% off every test — forever. Ends at 5,000 members.
Join 3,800+on the early access list · No spam · Unsubscribe anytime
Reviews
What our members discovered.
Real findings from real tests. These aren't marketing claims — they're what happens when you actually sequence the full microbiome.
★★★★★
I'd been told my gut was "normal" by two other tests. Biomeshield found Helicobacter cinaedi at the 99.9th percentile — an organism my gastroenterologist had never looked for. It explained symptoms I'd had for three years.
Michael R., 44
Functional medicine patient · New York
★★★★★
The tryptophan fate partitioning changed how I think about my depression. Seeing that 58% of my tryptophan was going down the kynurenine route — with the research to back it up — gave me something concrete to work with my psychiatrist on.
Sarah K., 36
Integrative health practitioner · Austin
★★★★★
The resistome findings were worth the test alone. After two courses of antibiotics last year, seeing my tetracycline resistance gene load and understanding the recovery protocol was exactly what I needed. Three months later the retest shows real improvement.
David L., 51
Biohacker · San Francisco
Questions
Frequently asked questions.
Everything you need to know before ordering.
How is shotgun different from 16S?
16S amplicon sequencing targets a single bacterial gene region — it misses fungi, viruses, archaea, and resistance genes entirely, and only reaches genus-level resolution. Shotgun metagenomics sequences all DNA in your sample, capturing everything across all kingdoms at species and strain level, plus functional gene output.
Does elevated abundance mean I have an infection?
No. Elevated abundance means an organism is present at higher levels than population norms — not that you have an active infection. Our report explains the spectrum from commensal to opportunistic to pathogenic, and recommends clinical follow-up only where warranted. This is a surveillance and optimisation tool, not a diagnostic device.
How long does it take to get results?
Standard turnaround is 10–14 days from sample receipt at the lab. Elite tier has a priority 7-day turnaround. You'll receive an email notification when your report is ready, with a link to your secure dashboard.
Is the test available outside the US?
Currently available in the United States and Canada. UK and EU availability coming Q3 2026. International shipping for research purposes may be available — contact us directly.
Can I share results with my doctor?
Yes — and we encourage it. Every finding includes clinical references with PMIDs so your physician can review the evidence base. Your report is downloadable as a print-ready PDF. We also offer practitioner portal access for clinicians who work with multiple patients.
How is my data handled?
Your raw sequencing data is stored encrypted and never sold. De-identified data may be used to improve our population reference cohort — you can opt out at any time. We are HIPAA compliant and use SOC 2 Type II certified infrastructure.
What do I need to do before collecting?
Avoid antibiotics for 4 weeks before collection if possible. No dietary restrictions required. Collect any time of day. Do not collect during or immediately after a gastrointestinal illness. Full instructions are included with your kit.
How often should I retest?
We recommend retesting every 8–12 weeks if you are actively working on intervention targets identified in your report. Annual testing is sufficient for ongoing surveillance if your results are in a healthy range. Longitudinal tracking becomes more valuable with each test.
Early Access · 20% Off Forever
Brain fog. Afternoon crashes.
Bloating that makes no sense.
Bloating that makes no sense.
These aren't mysteries — they're measurable.
Founding pricing ends at 5,000 members.
Founding pricing ends at 5,000 members.
No spam · Unsubscribe anytime · 3,800+ already joined
Get Started
Your microbiome holds
answers medicine
hasn't found yet.
Most diseases have a microbiome signature that appears years before symptoms. Biomeshield gives you the resolution to see it — and the knowledge to act on it.
Free shipping both ways · Results in 10–14 days · CLIA-certified lab · 100% satisfaction guarantee